Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC011
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-02-02 16:40
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl MADOPAR 1/2+1/4+1/4+1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 11 individuals with a value less than 0.55 were subsequently diagnosed with PD. That is, 26.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.55 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 21, 'TP': 18, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 23, 'TP': 15, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 28, 'TN': 18, 'TP': 14, 'FP': 12}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.56
timePerCircleCoV 0.115139
timePerCircleSlope -0.0136604
meanError 2.1385
tremorFreq 5.85938
tremorRelPower 32.1932
tremorGyroAmpMean 0.0209863
tremorGyroAmpSlope -0.00351008
tremorGyroAmpCoV 0.344059
tremorCoordAmpMean 0.201494
tremorCoordAmpSlope 0.00160988
tremorCoordAmpCoV 2.07321
tremorAccAmpMean 0.0601368
tremorAccAmpSlope -0.000640541
tremorAccAmpCoV 0.199415
tremorPcRelVar 0.680984
tremorPcX 0.356027
tremorPcY -0.934476

Circle Segment 1

Duration 7.96 s, Accuracy Estimate 1.164 (lower is better)

Circle Segment 2

Duration 7.64 s, Accuracy Estimate 1.808 (lower is better)

Circle Segment 3

Duration 9.04 s, Accuracy Estimate 1.6 (lower is better)

Circle Segment 4

Duration 8.44 s, Accuracy Estimate 1.624 (lower is better)

Circle Segment 5

Duration 5.96 s, Accuracy Estimate 3.196 (lower is better)

Circle Segment 6

Duration 7.64 s, Accuracy Estimate 4.195 (lower is better)

Circle Segment 7

Duration 6.6 s, Accuracy Estimate 1.837 (lower is better)

Circle Segment 8

Duration 7.32 s, Accuracy Estimate 2.099 (lower is better)

Circle Segment 9

Duration 7.24 s, Accuracy Estimate 1.914 (lower is better)

Circle Segment 10

Duration 7.76 s, Accuracy Estimate 1.948 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 23.62
timePerSpiralCoV 0.0587466
timePerSpiralSlope 0.0031509
meanError 1.7325
tremorFreq 6.44531
tremorRelPower 23.6226
tremorGyroAmpMean 0.0128848
tremorGyroAmpSlope -0.00152092
tremorGyroAmpCoV 0.384388
tremorCoordAmpMean 0.0556169
tremorCoordAmpSlope 0.00741075
tremorCoordAmpCoV 2.49863
tremorAccAmpMean 0.0247847
tremorAccAmpSlope -0.00139491
tremorAccAmpCoV 0.263213
tremorPcRelVar 0.542581
tremorPcX -0.559242
tremorPcY -0.829005

Spiral Segment 1

Duration 25.56 s, Accuracy Estimate 1.668 (lower is better)

Spiral Segment 2

Duration 21.6 s, Accuracy Estimate 1.624 (lower is better)

Spiral Segment 3

Duration 22.56 s, Accuracy Estimate 1.819 (lower is better)

Spiral Segment 4

Duration 23.68 s, Accuracy Estimate 1.53 (lower is better)

Spiral Segment 5

Duration 23.16 s, Accuracy Estimate 1.87 (lower is better)

Spiral Segment 6

Duration 22.48 s, Accuracy Estimate 2.087 (lower is better)

Spiral Segment 7

Duration 25.04 s, Accuracy Estimate 1.503 (lower is better)

Spiral Segment 8

Duration 23.72 s, Accuracy Estimate 1.531 (lower is better)

Spiral Segment 9

Duration 25.64 s, Accuracy Estimate 1.605 (lower is better)

Spiral Segment 10

Duration 22.76 s, Accuracy Estimate 2.087 (lower is better)

Elel

eDurationMean 0.573108
eDurationStd 0.0905565
eDurationStdnorm 0.15801
eDurationMedian 0.57
eDurationQuartdelta 0.07375
eDurationQuartdeltanorm 0.129386
eDurationKurt 3.96613
eDurationTrenddiff 0.015
eDurationTrendratio 1.02691
eWidthMean 1.73603
eWidthStd 0.794258
eWidthStdnorm 0.457514
eWidthMedian 1.521
eWidthQuartdelta 0.96525
eWidthQuartdeltanorm 0.634615
eWidthKurt 2.91524
eWidthTrenddiff -0.1755
eWidthTrendratio 0.892857
eHeightMean 6.318
eHeightStd 1.79845
eHeightStdnorm 0.284654
eHeightMedian 5.85
eHeightQuartdelta 2.457
eHeightQuartdeltanorm 0.42
eHeightKurt 3.41954
eHeightTrenddiff -0.234
eHeightTrendratio 0.961905
eAspectMean 0.269914
eAspectStd 0.0735548
eAspectStdnorm 0.272512
eAspectMedian 0.261905
eAspectQuartdelta 0.0877654
eAspectQuartdeltanorm 0.335104
eAspectKurt 3.16631
eAspectTrenddiff -0.0105081
eAspectTrendratio 0.960092
eSlantMean -0.00728718
eSlantStd 0.0996215
eSlantStdnorm -13.6708
eSlantMedian 0
eSlantQuartdelta 0.160461
eSlantQuartdeltanorm -22.0196
eSlantKurt 1.801
eSlantTrenddiff -0.0245796
eRtopMean 0.79161
eRtopStd 0.121367
eRtopStdnorm 0.153316
eRtopMedian 0.818182
eRtopQuartdelta 0.176923
eRtopQuartdeltanorm 0.216239
eRtopKurt 2.91494
eRtopTrenddiff 0.0492424
eRbotMean 0.869398
eRbotStd 0.368219
eRbotStdnorm 0.423533
eRbotMedian 0.777778
eRbotQuartdelta 0.575492
eRbotQuartdeltanorm 0.739919
eRbotKurt 2.51639
eRbotTrenddiff 0.00912698
eRrightMean 0.906247
eRrightStd 0.0728926
eRrightStdnorm 0.0804335
eRrightMedian 0.925
eRrightQuartdelta 0.107892
eRrightQuartdeltanorm 0.11664
eRrightKurt 3.02364
eRrightTrenddiff -0.0316807
eRleftMean 0.422385
eRleftStd 0.127803
eRleftStdnorm 0.302575
eRleftMedian 0.433962
eRleftQuartdelta 0.195797
eRleftQuartdeltanorm 0.451185
eRleftKurt 2.40388
eRleftTrenddiff -0.0268441
lDurationMean 0.876579
lDurationStd 0.128327
lDurationStdnorm 0.146395
lDurationMedian 0.865
lDurationQuartdelta 0.175
lDurationQuartdeltanorm 0.202312
lDurationKurt 2.71331
lDurationTrenddiff -0.135
lDurationTrendratio 0.856383
lWidthMean 3.159
lWidthStd 1.49363
lWidthStdnorm 0.472818
lWidthMedian 2.808
lWidthQuartdelta 1.404
lWidthQuartdeltanorm 0.5
lWidthKurt 8.47755
lWidthTrenddiff -1.053
lWidthTrendratio 0.689655
lHeightMean 14.8344
lHeightStd 2.8121
lHeightStdnorm 0.189567
lHeightMedian 14.4495
lHeightQuartdelta 3.978
lHeightQuartdeltanorm 0.275304
lHeightKurt 3.83143
lHeightTrenddiff -3.861
lHeightTrendratio 0.764286
lAspectMean 0.206276
lAspectStd 0.0633457
lAspectStdnorm 0.307091
lAspectMedian 0.19823
lAspectQuartdelta 0.0558065
lAspectQuartdeltanorm 0.281524
lAspectKurt 9.11126
lAspectTrenddiff -0.0468591
lAspectTrendratio 0.792481
lSlantMean 0.0554667
lSlantStd 0.0917832
lSlantStdnorm 1.65475
lSlantMedian 0.0420363
lSlantQuartdelta 0.097561
lSlantQuartdeltanorm 2.32088
lSlantKurt 5.99514
lSlantTrenddiff -0.0769424
lRtopMean 0.819914
lRtopStd 0.110169
lRtopStdnorm 0.134367
lRtopMedian 0.836667
lRtopQuartdelta 0.128889
lRtopQuartdeltanorm 0.15405
lRtopKurt 3.88135
lRtopTrenddiff -0.0625
lRbotMean 0.627379
lRbotStd 0.33582
lRbotStdnorm 0.535275
lRbotMedian 0.606602
lRbotQuartdelta 0.38057
lRbotQuartdeltanorm 0.627381
lRbotKurt 5.99442
lRbotTrenddiff 0.322464
lRrightMean 0.918992
lRrightStd 0.0550425
lRrightStdnorm 0.0598944
lRrightMedian 0.919409
lRrightQuartdelta 0.0515142
lRrightQuartdeltanorm 0.0560296
lRrightKurt 8.97262
lRrightTrenddiff 0.0139931
lRleftMean 0.331618
lRleftStd 0.158873
lRleftStdnorm 0.479086
lRleftMedian 0.295174
lRleftQuartdelta 0.200348
lRleftQuartdeltanorm 0.678747
lRleftKurt 3.27249
lRleftTrenddiff 0.07661

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.688527
sumTouchScores 14.4591
meanMovementTime 0.9585
numTouches 21
undershootPercentage 14.2857
overshootPercentage 33.3333

FITTS Long Modified

meanTouchScore 0.909293
sumTouchScores 13.6394
meanMovementTime 1.175
numTouches 15
undershootPercentage 0
overshootPercentage 13.3333

ZigZag

numZigzags 5
timePerZigzagMean 35.928
timePerZigzagCoV 0.17116
timePerZigzagSlope 0.0298375
meanError 2.19342
tremorFreq 6.44531
tremorRelPower 28.871
tremorGyroAmpMean 0.0208487
tremorGyroAmpSlope -0.000551391
tremorGyroAmpCoV 0.393208
tremorCoordAmpMean 0.0400841
tremorCoordAmpSlope -0.00167035
tremorCoordAmpCoV 0.277551
tremorAccAmpMean 0.0346619
tremorAccAmpSlope -0.00142604
tremorAccAmpCoV 0.297528
tremorPcRelVar 0.717702
tremorPcX 0.424001
tremorPcY -0.905662

ZigZag Segment 1

Duration 40.8 s, Accuracy Estimate 1.995 (lower is better)

ZigZag Segment 2

Duration 29.8 s, Accuracy Estimate 1.922 (lower is better)

ZigZag Segment 3

Duration 29.0 s, Accuracy Estimate 1.705 (lower is better)

ZigZag Segment 4

Duration 37.96 s, Accuracy Estimate 2.635 (lower is better)

ZigZag Segment 5

Duration 42.08 s, Accuracy Estimate 2.71 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 30.832
timePerZigzagCoV 0.0785804
timePerZigzagSlope -0.0108978
zigzagHeightMean 91.5692
zigzagHeightCoV 0.0255045
zigzagHeightSlope -0.0150703
meanError 0.0606164
tremorFreq 6.93359
tremorRelPower 23.4673
tremorGyroAmpMean 0.0445203
tremorGyroAmpSlope 0.00126902
tremorGyroAmpCoV 1.17798
tremorCoordAmpMean 0.0442214
tremorCoordAmpSlope 8.90449e-05
tremorCoordAmpCoV 0.259296
tremorAccAmpMean 0.056848
tremorAccAmpSlope -0.000174352
tremorAccAmpCoV 1.2108
tremorPcRelVar 0.815213
tremorPcX -0.263034
tremorPcY -0.964786

ZigZag Offset Segment 1

Duration 30.64 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 2

Duration 34.4 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 3

Duration 27.56 s, Accuracy Estimate 0.126 (lower is better)

ZigZag Offset Segment 4

Duration 30.8 s, Accuracy Estimate 0.056 (lower is better)

ZigZag Offset Segment 5

Duration 30.76 s, Accuracy Estimate 0.034 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.33}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.55}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9702709298573144}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9002518185055648}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.864451033586261}